The B5074 between Worleston and Church Minshull will close for 10 days to allow improvements and repairs.
Cheshire East Council says the works will bring highways improvements between the junction of Over Road and Cross Lane and the A51 Reaseheath roundabout.
It will be shut between the hours of 9.30am and 3.30pm from January 25 to February 5.
Highways teams will be gully cleaning, sign cleaning, carrying out grass verges and footway maintenance.
Work is planned outside of peak travel hours when the route will be open.
Any winter maintenance gritting activities will go ahead as planned.
A diversion route will be in place while works are in progress and will be signed via the A530.
This route will be mapped out using advanced warning variable message signs at several locations.
Emergency access will be maintained and local residents and businesses have been informed.
Staff will be posted at closure points to allow entry and exit to properties and businesses in Church Minshull and Worleston.
Follow updates on Twitter @CECHighways and at cheshireeast.gov.uk/highways
Any queries, contact Cheshire East Council customer contact centre on 0300 123 5020.
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